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Myelin is a protective layer that coats your nerves, kind of like the plastic coating around electrical wires

Regarding the mentioned studies, it seems that a higher dosage of folic acid especially in combination with B6 and B12 could alleviate the symptoms of migraine

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doi:10.1371/journal.pone.0033944 Lederman RJ, Mendelsohn FO, Anderson RD, Saucedo JF, Tenaglia AN, Hermiller JB, Hillegass WB, Rocha-Singh K, Moon TE, Whitehouse MJ et al (2002) Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial

Safety and efficacy results from the expansion phase of the first-in-human study evaluating TGF inhibitor SAR439459 alone and combined with cemiplimab in adults with advanced solid tumors